Episode 41: Evidence with Anne - Gynaeoncology
Landmark trials, Gynaeoncology Melissa Acreman Landmark trials, Gynaeoncology Melissa Acreman

Episode 41: Evidence with Anne - Gynaeoncology

In this electrifying episode of The Uterine Sound podcast, hosts Carla Pecoraro, Mel Acreman, and Anne Woolfield dive into groundbreaking gynaecology oncology research that could transform patient care.

First, we unravel the mysteries of the PLCO study—“Effect of Screening on Ovarian Cancer Mortality.” This 2011 JAMA blockbuster pits CA125 and transvaginal ultrasound against routine care in a high-stakes battle for ovarian cancer mortality. With over 78,000 women in the mix, the results are eye-opening: while screening increased cancer diagnoses, it didn’t cut mortality rates. Plus, the fallout from false positives led to serious complications. Tune in to find out why this study could reshape how we think about ovarian cancer screening.

Next, the podcast heats up with the LACE trial—“Effect of Total Laparoscopic Hysterectomy vs Total Abdominal Hysterectomy on Disease-Free Survival.” Published in 2017, this study compares laparoscopic hysterectomy to the traditional abdominal approach in treating stage 1 endometrial cancer. Discover how TLH stacks up against TAH in terms of disease-free survival and why TLH's benefits might make it the new gold standard for quicker recoveries and less post-op pain.

Get ready for a dynamic episode packed with crucial insights from these landmark trials. Whether you're a clinician or just curious, this episode delivers cutting-edge information that’s essential for understanding and improving gynaecological cancer care. Don’t miss out—this is a must-listen for anyone invested in women's health!

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Episode 34: Evidence with Anne - Early Pregnancy
Landmark trials Melissa Acreman Landmark trials Melissa Acreman

Episode 34: Evidence with Anne - Early Pregnancy

Join hosts Carla, Mel, and Anne as they delve into groundbreaking RANZCOG landmark trials on early pregnancy in this must-listen episode of the Uterine Sound podcast. Discover how they turn complex, landmark studies into bite-sized, exam-ready insights.

In this episode, the hosts break down major trials exploring treatments for recurrent miscarriage, including the effectiveness of low molecular weight heparin and aspirin, and compare medical versus surgical management of miscarriage. Learn how these studies influence current practices and what the latest evidence means for clinical decisions in obstetrics and gynaecology.

Perfect for busy professionals, this episode transforms dense medical research into practical knowledge you can digest on the go. Stay informed and up-to-date with the latest in O&G by tuning in, and connect with us on Instagram @theuterinesound or visit our website theuterinesound.com.

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Episode 25: Evidence with Anne - The Term Breech Trial
Landmark trials Melissa Acreman Landmark trials Melissa Acreman

Episode 25: Evidence with Anne - The Term Breech Trial

Join hosts Carla, Mel, and Anne for another insightful episode of The Uterine Sound podcast, where they delve into the intricacies of obstetrics and gynecology. In this latest "Evidence with Anne" episode, the trio takes on the mammoth topic of the Term Breech Trial.

Carla, Mel, and Anne break down the study design, outcomes, and implications of this pivotal trial, providing listeners with a comprehensive understanding of its significance in the field. From discussing the randomization process and participant demographics to dissecting the primary and secondary outcomes, no stone is left unturned.

Through engaging conversation and a touch of humour, the hosts navigate through the complexities of the trial, addressing strengths, limitations, and common themes that emerge. They offer valuable insights into the implications of the trial results on clinical practice, examining shifts in obstetric care and the evolving landscape of breech deliveries.

Whether you're a seasoned practitioner, a medical student, or simply curious about the latest in O&G, this episode of The Uterine Sound podcast is sure to inform and inspire. Tune in for an enlightening discussion that promises to deepen your understanding of one of the most significant trials in obstetrics history.

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Episode 18: Evidence with Anne - Antenatal Corticosteroids
Landmark trials Melissa Acreman Landmark trials Melissa Acreman

Episode 18: Evidence with Anne - Antenatal Corticosteroids

Embark on a journey through obstetrics and gynaecology with the Uterine Sound podcast! In this captivating episode of "Evidence with Anne," the hosts explore the landmark trials on antenatal corticosteroids – ACTORDS, ASTEC, and ALPS, along with the 2020 Cochrane review. Join Carla, Mel, and Anne as they unravel the fascinating history of steroids for fetal lung maturation, originating from a serendipitous discovery in New Zealand. Discover how these steroids became a game-changer for preterm babies' health.

The hosts dissect the ACTORDS trial, revealing the impact of repeat doses of betamethasone on neonatal morbidity. Delve into the ASTEC trial, where elective caesarean births at term face scrutiny regarding respiratory distress. Uncover the ALPS trial, exploring the use of betamethasone in late preterm deliveries and its effects on neonatal outcomes.

But wait, there's more! The episode wraps up with insights from the 2020 Cochrane review, providing a comprehensive summary of the benefits and potential downsides of antenatal corticosteroids. Get ready for an engaging discussion, complete with surprising findings, intriguing historical anecdotes, and essential insights into the world of O&G. Tune in to the Uterine Sound podcast for a journey through the evidence behind steroids in pregnancy – because the quest for knowledge never sounded so compelling!

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Episode 14: Evidence with Anne - Magnesium Sulphate
Landmark trials, Obstetrics Melissa Acreman Landmark trials, Obstetrics Melissa Acreman

Episode 14: Evidence with Anne - Magnesium Sulphate

Join the Uterine Sound podcast hosts, Carla, Anne, and Mel, as they delve into the thrilling world of O&G research in their latest "Evidence with Anne" episode. In this episode, they explore the groundbreaking use of Magnesium Sulfate in the prevention of eclampsia and fetal neuroprotection, featuring the monumental MAGPIE trial and a Cochrane review. With insightful details, they unravel the history, inclusion criteria, and remarkable outcomes. Discover how Magnesium Sulfate halves the risk of eclampsia and reduces the rate of cerebral palsy in preterm infants . Don't miss the latest addition to their discussion, the Magenta trial, which reveals whether the benefits extend to infants born between 30 and 34 weeks. Tune in to The Uterine Sound for the most up-to-date insights in the world of O&G research!

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Episode 10: Evidence with Anne - Progesterone
Landmark trials Melissa Acreman Landmark trials Melissa Acreman

Episode 10: Evidence with Anne - Progesterone

Welcome to another electrifying episode of Evidence with Anne on The Uterine Sound. Unveiling RANZCOG's landmark trials on progesterone's role in preventing preterm birth, the hosts dissect two groundbreaking studies. In a whirlwind of enthusiasm, the trio sets the stage, opting to spotlight these landmark trials amid the sea of progesterone research. The episode zooms in on the 2003 trial "Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: A randomised placebo-controlled double-blind study" then energy escalates as the focus shifts to the second landmark trial "Progesterone and the risk of preterm birth among women with a short cervix".

The hosts deftly convey the study's incredible discovery: vaginal progesterone's profound impact on reducing preterm births.

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Episode 6: Evidence with Anne - PPROM
Landmark trials Melissa Acreman Landmark trials Melissa Acreman

Episode 6: Evidence with Anne - PPROM

Get ready for the debut episode of "Evidence with Anne" on the thrilling Uterine Sound podcast! Hosted by the dynamic trio, Carla, Mel, and Anne, this episode dives deep into the pulse-pounding world of Preterm Prelabour Rupture of Membranes (PPROM) and its landmark trials.

Hold your breath as they unravel the mysteries of the ORACLE I trial, where antibiotics take centre stage in the epic battle for neonatal outcomes. Discover the power of erythromycin, the hero reducing morbidity and mortality, while the sinister co-amoxiclav raises the spectre of NEC.

But the action doesn't stop there! The ORACLE II trial enters the fray, adding a twist to the tale with its unexpected findings. Brace yourself as the hosts navigate through functional impairments and cerebral palsy, shedding light on the long-term effects of these treatments.

In a heart-pounding showdown, the PPROMT trial takes the spotlight, where immediate delivery faces off against expectant management. Witness the fierce clash of neonatal sepsis rates, respiratory distress, and NICU battles, while APH and caesarean sections add to the adrenaline rush.

And just when you think the excitement is over, the PPROMEXIL trial steps into the ring with its 10-year follow-up! Can it provide the answers to the ultimate question: What are the long-term outcomes for these little warriors?

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